NR ATQN
AU Kumar,J.; Richter,C.; Grimme,S.; Vonck,J.; Glaubitz,C.; Schwalbe,H.
TI Residual Structure of Human Prion Protein 121-230 under Non-native Conditions
QU International Conference - Prion 2005: Between fundamentals and society's needs - 19.10.-21.10.2005, Congress Center Düsseldorf - Poster Session: Structure of PrP and molecular determinants of infectivity STRCT-03
PT Konferenz-Poster
AB In the present study, we focused on the human prion protein 121-230 (hPrP 121-230) when studied under non-native [conditions]. This is important towards the understanding of fibril formation by hPrP 121-230 under these conditions. NMR observations with hPrP 121-230 gives a molecular insight in the residual structure of hPrP 121-230. we have observed fibrillation and amyloidic gel formation on prolong[ed] incubation of hPrP 121-230. Solution and Solid-state NMR data reveals the presence of a flexible as well as a rigid region in such fibrils. The result of NMR assignment will be discussed. This assignment will lead us towards better understanding of PrPc -> PrPsc formation.
AD Jitendra Kumar, Christian Richter, Sussane Grimme, Harald Schwalbe, Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Universität Frankfurt am Main, Germany; Janet Vonck, Department of Structural Biology, Max Planck Institute for Biophysics, Frankfurt am Main; Clemens Glaubitz, Institute for Biophysical Chemistry, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Universität Frankfurt am Main, Germany
SP englisch
PO Deutschland