NR ATSK
AU Windl,O.; Buchholz,M.; Neubauer,A.; Schulz-Schaeffer,W.J.; Groschup,M.H.; Walter,S.; Arendt,S.; Neumann,M.; Voss,A.K.; Kretzschmar,H.A.
TI Breaking an absolute species barrier: transgenic mice expressing the mink PrP gene are susceptible to transmissible mink encephalopathy.
QU Journal of Virology 2005 Dec; 79(23): 14971-5
PT journal article
AB Transmissible mink encephalopathy (TME) is a rare disease of the North American mink, which has never been successfully transmitted to laboratory mice. We generated transgenic mice expressing the mink prion protein (PrP) and inoculated them with TME or the mouse-adapted scrapie strain 79A. TME infected mink PrP-transgenic mice on a murine PrP knockout background. The absolute species barrier between the infectious agent of TME and mice was therefore broken. Following TME and 79A infection of mice carrying both mink and murine PrPc, only proteinase-resistant PrP homologous to the incoming agent was detectable. The presence of the murine PrPc prolonged the incubation time of TME substantially.
MH Animals; Disease Models, Animal; Gene Transfer Techniques; Mice; Mice, Transgenic; Mink; PrPsc Proteins/genetics/metabolism/*pathogenicity; Prion Diseases/metabolism/pathology/transmission/*veterinary; Prions/*genetics; Research Support, Non-U.S. Gov't
AD University of Munich, Istitute of Neuropathology, München, Germany.
SP englisch
PO USA