NR ATTL
AU Gurau,C.; Zeghoudi,A.C.; Atlaoui-Rabia,S.; Charitanski,D.; Mallecourt,J.
TI [Cerebral magnetic resonance imaging in iatrogenic Creutzfeldt-Jakob disease]
OT Imagerie par resonance magnetique cerebrale dans la maladie de Creutzfeldt-Jakob iatrogene
QU Presse Medicale 2005 Sep 10; 34(15): 1080-1
PT case reports; journal article
AB INTRODUCTION: We describe here the cerebral cerebral magnetic resonance (MRI) abnormalities observed in a case of iatrogenic Creutzfeldt-Jakob disease (CD). CASE: A 37 year-old man had been treated for pituitary dwarfism during adolescence with contaminated growth hormone. Neurological symptoms nearly two decades later suggested CJD. Cerebral MRI nine months after the onset of symptoms showed hypersignals similar to those observed in variant CJD (pulvinar sign). The diagnosis of CJD was confirmed by post-mortem examination. DISCUSSION: To our knowledge, this is the first case in which MRI revealed iatrogenic CD. The aspects are similar to those described for variant CJD.
MH Adolescent; Adult; Age Factors; Brain/*pathology; Creutzfeldt-Jakob Syndrome/*diagnosis/etiology/pathology; *Drug Contamination; Dwarfism, Pituitary/*drug therapy; English Abstract; Human Growth Hormone/*therapeutic use; Humans; *Iatrogenic Disease; *Magnetic Resonance Imaging; Male; Time Factors
AD Service d'endocrinologie, CH de Dreux (28).
SP französisch
PO Frankreich