NR ATUD
AU Nakayashiki,T.; Kurtzman,C.P.; Edskes,H.K.; Wickner,R.B.
TI Yeast prions [URE3] and [PSI+] are diseases
QU Proceedings of the National Academy of Sciences of the United States of America 2005 Jul 26; 102(30): 10575-80
IA http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1180808
PT journal article
AB Viruses, plasmids, and prions can spread in nature despite being a burden to their hosts. Because a prion arises de novo in more than one in 10(6) yeast cells and spreads to all offspring in meiosis, its absence in wild strains would imply that it has a net deleterious effect on its host. Among 70 wild Saccharomyces strains, we found the [PIN+] prion in 11 strains, but the [URE3] and [PSI+] prions were uniformly absent. In contrast, the "selfish" 2mu DNA was in 38 wild strains and the selfish RNA replicons L-BC, 20S, and 23S were found in 8, 14, and 1 strains, respectively. The absence of [URE3] and [PSI+] in wild strains indicates that each prion has a net deleterious effect on its host.
MH Comparative Study; Green Fluorescent Proteins; Oligonucleotides; Plasmids/genetics; Prions/*genetics; Replicon/genetics; Saccharomyces/*genetics; Saccharomyces cerevisiae Proteins/*genetics; Species Specificity
AD Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8, Room 225, Bethesda, MD 20892-0830, USA
SP englisch
PO USA