NR ATUX
AU Tabner,B.J.; Turnbull,S.; Fullwood,N.J.; German,M.; Allsop,D.
TI The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?
QU Biochemical Society Transactions 2005 Aug; 33(4): 548-50
PT journal article
AB By means of an ESR spin-trapping method, we have shown that Abeta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.
MH Amyloid/metabolism; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrogen Peroxide/*metabolism; Nerve Degeneration/*physiopathology; Oxidative Stress/*physiology; Peptides; Research Support, Non-U.S. Gov't
AD Magnetic Resonance Laboratory, University of Lancaster, Lancaster LA1 4YQ, UK
SP englisch
PO England