NR ATVJ
AU Kixmöller,M.
TI [Reference ranges for laboratory values of different pig breeds as well as histopathological and immunohistochemical investigation of brains of older sows and boars of transmissible spongiform encephalopathy in the course of the TSE-study]
OT Labordiagnostische Referenzbereiche bei unterschiedlichen Schweinerassen sowie histopathologische und immunhistochemische Untersuchung von Gehirnen älterer Sauen und Eber auf transmissible spongiforme Enzephalopathie im Rahmen der TSE-Studie
QU Inaugural-Dissertation zur Erlangung der tiermediznischen Doktorwürde der Tierärztlichen Fakultät der Ludwig-Maximilians-Universität München von Marion Kixmöller aus Villingen-Schwenningen, München 13.2.2004
IA http://edoc.ub.uni-muenchen.de/archive/00002198/
PT Dissertation
AB
The aim of the present study was to make a statement about selected blood ingredients for twelve pig breeds regarding the influence of the genotype. A possible race-dependence was proved for haematological parameters especially for erythrocytes, thrombocytes and leucocytes. Differences between the breeds were also found for electrolytes and the trace elements although a statement concerning breed-specifity was more difficult because some other environmental factors can have strong influence on these parameters as well. In part clear differences, which are caused by different physical characteristics and attributes of the animals such as muscle mass and susceptibility to stress, were established for substrates and enzymes. We were able to show that the pietrain pigs possess a remarkably higher concentration of some blood ingredients, in comparison with ?German Landrace and Edelschwein?. To conclude, the results show, that there are marked differences in characteristics. We detected a varying influence of the genotype on the hematological and chemical blood parameters. The varying concentration of the blood parameters in the examined breeds seems to result from breed-specific metabolism and resistance to infections and environmental influence.
The immune-histochemical search for accumulation of pathological prion protein with the antibody L42 in 48 brain tissue sections of both sows and boars was negativ. Nonetheless, it is possible to experimentally infect pigs with the infectious prion protein from cattle. This means that, in spite of the species-barrier, even though the infection was transmitted parenterally, pigs, along with many other animals, are susceptible to an infection with the bseagent. There is a definite need for acquiring further knowledge on the exact onset of and events during infection and on the degree of contagiousness of transmissible spongiform encephalopathy not only in swine.
IN Im Rahmen ihrer sprachlich und zumindest im Bezug auf TSE erschreckend fehlerhaften Dissertation suchte Marion Kixmöller lediglich mit dem einen Antikörper mab L42 in formalinfixierten und in Paraffin eingebetteten Hirnstammschnitten von 48 maximal 5 Jahre alten Schweinen per Immunhistochemie vergeblich nach PrPsc-Akkumulationen.
AD Marion Kixmöller aus der Klinik für Schweine (Vorstand: Prof. Dr. Dr. habil. Karl Heinritzi) der Tierärztlichen Fakultät der Ludwig-Maximilians-Universität München
SP deutsch
PO Deutschland