NR ATWD
AU Zanusso,G.; Fiorini,M.; Farinazzo,A.; Gelati,M.; Benedetti,M.D.; Ferrari,S.; Dalla Libera,A.; Capaldi,S.; Monaco,H.L.; Rizzuto,N.; Monaco,S.
TI Phosphorylated 14-3-3zeta protein in the CSF of neuroleptic-treated patients
QU Neurology 2005 May 10; 64(9): 1618-20
PT journal article
AB The authors describe 12 neuroleptic-treated patients with dementia of various etiologies who showed CSF elevation of phosphorylated 14-3-3zeta and normal tau protein levels. This contrasted with elevated amounts of 14-3-3 gamma, epsilon, and unphosphorylated zeta coupled to high tau protein levels in Creutzfeldt-Jakob disease and negative 14-3-3 assay in drug-free patients with dementia. Characterization of CSF 14-3-3 isoforms and determination of tau protein level can help to distinguish different etiologies of dementia.
MH 14-3-3 Proteins/*cerebrospinal fluid; Aged; Aged, 80 and over; Antipsychotic Agents/*pharmacology/therapeutic use; Biological Markers/cerebrospinal fluid; Brain/metabolism/physiopathology; Creutzfeldt-Jakob Syndrome/cerebrospinal fluid/diagnosis; Dementia/*cerebrospinal fluid/*diagnosis/drug therapy; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Phosphorylation; Predictive Value of Tests; Protein Isoforms/cerebrospinal fluid; Reference Values; Research Support, Non-U.S. Gov't; Up-Regulation/physiology; tau Proteins/*cerebrospinal fluid
AD Department of Neurological and Visual Sciences, University of Verona, Verona, Italy.
SP englisch
PO USA