NR AUAO
AU Hardy,J.; Scholz,S.; Evans,W.; Goldfarb,L.; Singleton,A.
TI Prion genotypes in Central America suggest selection for the V129 allele
QU American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the official publication of the International Society of Psychiatric Genetics 2006 Jan 5; 141(1): 33-5
PT journal article
AB Using the well-characterized, human diversity sample series, we show that the V129 prion allele has a very high frequency in South American populations relative to the East Asian populations from which it arose. We suggest there has been selection at the prion locus, possibly mediated by Kuru-like diseases, which has influenced its allele frequency.
MH Alleles; Central America; Gene Frequency; Genotype; Humans; Prions/*genetics; *Selection (Genetics); South America; Valine/*genetics; Variation (Genetics)
AD Laboratory of Neurogenetics, National Institute on Aging, Porter Neuroscience Building, 35 Convent Drive, Bethesda, MD 20892, USA. hardyj@mail.nih.gov
SP englisch
PO USA