NR AUCK
AU de Paula,E.V.; Addas-Carvalho,M.; Costa,D.S.; Saad,S.T.; Gilli,S.C.
TI Genotype frequencies at codon 129 of the prion protein gene in Brazil: Implications in susceptibility to variant Creutzfeldt-Jakob disease compared to European and Asian populations.
QU European Journal of Epidemiology 2005; 20(7): 593-5
PT journal article
AB A polymorphism at codon 129 of the prion protein gene has been shown to confer genetic susceptibility to prion diseases, and to influence the epidemic course of variant Creutzfeldt-Jakob disease. We employed a PCR-endonuclease digestion-based assay to investigate this genetic trait in Brazil, and then compared our results to previously published data from several European and Asian countries.
MH Adolescent; Adult; African Continental Ancestry Group/genetics; Aged; Asian Continental Ancestry Group/genetics; Brazil; Codon/*genetics; Comparative Study; Creutzfeldt-Jakob Syndrome/epidemiology/ethnology/*genetics; European Continental Ancestry Group/genetics; Gene Frequency/*genetics; Genetic Predisposition to Disease/epidemiology; *Genotype; Humans; Indians, South American/genetics; Middle Aged; Peptide Fragments/*genetics; Polymerase Chain Reaction; *Polymorphism, Genetic; Prions/*genetics; Quantitative Trait, Heritable
AD Haematology and Haemotherapy Centre, State University of Campinas, Rua Carlos Chagas 480, CEP 13083-970 Campinas, SP, Brazil.
SP englisch
PO Niederlande