NR AUFG
AU Stoltenburg-Didinger,G.
TI Prion diseases
OT Durch Prione verursachte Krankheiten
QU Fleischwirtschaft 2002 Jul 15; 82(7): 107-10
PT article
AB The term,prion diseases" refers to a group of neuro degenerative disorders thought to be caused by prions, pathogenetic agents with novel modes of replication and transmission. Prion diseases are characterized by a long incubation period ranging from months to years and decades and are invariably fatal once clinical symptoms have appeared. They are also called transmissible spongiform encephalopathies (TSE), on account of the predominant neuropathological change observed in the central nervous system. The most important members of this group are Creutzfeldt-Jakob disease (CJD) of man displaying sporadic, inherited and infectious forms, bovine spongiform encephalopathy (BSE) of cattle, and scrapie of sheep and goat. Despite their rarity, human prion diseases have recently been covered extensively in the media because of the likely connection between a new variant of human CJD (vCJD) and BSE and the possibility of contamination of human blood and blood products by the vCJD agent. The clinical and neuropathological features of the most important human prion diseases will be presented.
SP deutsch
PO Deutschland