NR AULG
AU Lefrancois,T.; Tardy,M.
TI Astrocyte as the key cell in the pathogenesis of spongiform encephalopathy
QU Recueil de Medecine Veterinaire 1995; 171(1): 29-32
PT Article
AB Astrocyte is the major cell type in the central nervous system. This cell assume numerous functions in the brain development, in the development and the integrity of the blood-brain barrier, in the neuron-glie interaction and in the brain homeostasia. Spongiform encephalopathies are characterized by a major and early astrocyte reactivity with hypertrophy and hyperplasie of this very plastic cell. Binding of the Prion protein with the major component of the gliofilament (GFAP) could identify the astrocyte as responsible for the conversion of the membranal protein in an abnormal protein. Moreover, astrocyte is able to accumulate this protein. The consequent gene alteration, implicate astrocyte in the amyloid formation, and in the neuronal lesions. This show that astrocyte try to maintain an intact neuron-glia interaction. All these feature give to the astrocyte a key role in spongiform encephalopathie pathogenesis.
ZR 0
SP französisch