NR AUNH
AU Del Bo,R.; Scarlato,M.; Ghezzi,S.; Martinelli-Boneschi,F.; Fenoglio,C.; Galimberti,G.; Galbiati,S.; Virgilio,R.; Galimberti,D.; Ferrarese,C.; Scarpini,E.; Bresolin,N.; Comi,G.P.
TI Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis
QU Neurobiology of Aging 2006 May; 27(5): 770.e1-770.e5
PT journal article; meta-analysis
AB The methionine/valine (M/V) polymorphism at codon 129 within the prion protein gene (PRNP) represents a known risk factor for Creutzfeldt-Jakob disease (CJD). Few authors reported also the effects of this polymorphism on the risk of Alzheimer's disease (AD), although with controversial results. To better clarify this issue, we performed a novel case-control study and a meta-analysis of published association studies between PRNP and AD. Our findings argue against PRNP as a susceptibility gene for developing AD in the Italian population but support the hypothesis that the V allele influences cognitive performances. The meta-analysis, revealed that Caucasian subjects homozygous at codon 129 had a 1.3-fold increased risk [95% CI: 1.0-1.6, p = 0.05] of developing AD compared to heterozygous individuals. We also observed that MM genotype and M allele represent a risk factor for AD, independently from the ethnic background, providing a significant but modest association between this polymorphism and AD.
MH Aged; Alleles; Alzheimer Disease/epidemiology/*genetics/psychology; Amyloid/*genetics; Apolipoproteins E/genetics; Case-Control Studies; Cognition/physiology; DNA/genetics; Female; Gene Frequency; Genotype; Humans; Italy/epidemiology; Male; Neuropsychological Tests; Polymorphism, Genetic/genetics; Protein Precursors/*genetics; Research Support, Non-U.S. Gov't
AD Dino Ferrari Centre, Department of Neurological Sciences, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Padiglione Ponti, Milano, Italy. roberto.delbo@unimi.it
SP englisch
PO USA