NR AUQS
AU Tavan,P.
TI Computational support for prion research
QU TSE-Forum, 6. Kongress - Nationale TSE-Forschungsplattform, Greifswald 26.6.-28.6.2006, Vortrag V-11
PT Konferenz-Vortrag
AB
Theoretical (Bio-)Physics is a branch of science from which one hardly would expect relevant contributions to prion research. Nevertheless, such contributions can be achieved within interdisciplinary and closely cooperative efforts integrating neuropathology, cell biology, biochemistry and pharmacology. The talk will serve to explain and review the kind of input to prion research that can be provided to prion research by taking three examples from our recent research as an illustration. These examples cover the computational analysis of pharmaceutical screening data on anti-TSE compounds and computer simulations on the stability of the cellular prion protein as well as of models for amyloid aggregation nuclei in neurodegenerative diseases.
Literature:
U. Bertsch et al. (2005). Systematic identification of anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (SIFT). J. Virol. 79, 7785-7791.
T. Hirschberger et al. (2006). Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulations Biophys. J. (in press).
M. Stork et al (2005). MD simulations indicate a possible role of parallel beta-helices in seeded aggregation of poly-Gln. Biophys. J. 88, 2442-2451.
AD Paul Tavan, Lehrstuhl für BioMolekulare Optik, Theoretische Biophysik, Ludwig-Maximilians-Universität München, Oettingenstr. 67, 80538 München
SP englisch
PO Deutschland
OR Tagungsband