NR AUSZ
AU Mok,S.W.F.; Thelen,K.M.; Riemer,C.; Bamme,T.; Gültner,S.; Lütjohann,D.; Baier,M.
TI Simavastatin-treatment prolongs survival times in a murine prion model
QU TSE-Forum, 6. Kongress - Nationale TSE-Forschungsplattform, Greifswald 26.6.-28.6.2006, Poster: Therapie THE-05
PT Konferenz-Poster
AB Prion diseases are fatal and there are at present neither cures nor palliative therapies to delay disease onset or progression known. Cholesterol-lowering drugs have been reported to inhibit prion replication in infected cell-cultures and to modulate inflammatory reactions. We aimed to determine whether simvastatin-treatment could delay disease onset in a murine prion model. Groups of mice were intracerebrally infected with two doses of scrapie strain 139A. Simvastatin treatment commenced 100 days post infection. The scrapie infection was characterized analyzing PrPres deposition and by detection of alterations of disease-associated inflammatory reactive gliosis. Simvastatin treatment significantly delayed disease progression and prolonged survival times in established prion infection of the CNS (p<=0.0003). Immunohistochemical comparison of treated versus untreated mice revealed profound alterations concerning the expression of glial signature markers indicating a modulation of glia activation. The results encourage clinical trials with statins for palliative treatment of Creutzfeldt-Jakob disease.
AD Mok Wing Fai Simon, Constanze Riemer, Theresa Bamme, Sandra Gültner, Michael Baier, Project Neurodegenerative Diseases, Robert-Koch-Institute, Nordufer 20, 13353 Berlin, Germany; Karin M. Thelen, Dieter Lütjohann, Department of Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany
SP englisch
PO Deutschland
EA Photo des in Greifswald gezeigten noch unfertigen Posters, dessen Autorenliste aber laut Auskunft von Dr. Baier im Gegensatz zum Tagungsband gelten soll, Details
OR Tagungsband