NR AUXZ
AU Armstrong,R.A.; Cairns,N.J.; Ironside,J.W.
TI Size frequency distributions of the florid prion protein aggregates in variant Creutzfeldt-Jakob disease follow a power-law function
QU Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2006 Jun; 27(2): 104-9
PT journal article
AB The objective was to test the hypothesis that the size frequency distributions of the prion protein (PrP) plaques in cases of variant Creutzfeldt-Jakob disease (vCJD) follow a power-law function. The design was a retrospective neuropathological study. The patients were 11 cases of clinically and neuropathologically verified vCJD. Size distributions of the diffuse and florid-type plaques were measured in several areas of the cerebral cortex and hippocampus from each case and a power-law function fitted to each distribution. The size distributions of the florid and diffuse plaques were fitted successfully by a powerlaw function in 100% and 42% of brain areas investigated respectively. Processes of aggregation/disaggregation may be more important than surface diffusion in the pathogenesis of the florid plaques. By contrast, surface diffusion may be a more significant factor in the development of the diffuse plaques.
MH Adolescent; Adult; Brain/metabolism/*pathology; Creutzfeldt-Jakob Syndrome/*pathology; Female; Humans; Male; Middle Aged; Prions/*metabolism; Research Support, Non-U.S. Gov't; Retrospective Studies
AD Vision Sciences, Aston University, Birmingham B4 7ET, and National CJD Surveillance Unit, Western General Hospital, Edinburgh, UK. R.A.Armstrong@aston.ac.uk
SP englisch
PO Italien