NR AUZQ
AU Pinheiro,T.J.T.
TI The role of rafts in the fibrillization and aggregation of prions
QU Chemistry and Physics of Lipids 2006 Jun; 141(1-2): 66-71
PT journal article; review
AB A key molecular event in prion diseases is the conversion of the prion protein (PrP) from its normal cellular form (PrPc) to the disease-specific form (PrPsc). The transition from PrPc to PrPsc involves a major conformational change, resulting in amorphous aggregates and/or fibrillar amyloid deposits. Here several lines of evidence implicating membranes in the conversion of PrP are reviewed with a particular emphasis on the role of lipid rafts in the conformational transition of prion proteins. New correlations between in vitro biophysical studies and findings from cell biology work on the role of rafts in prion conversion are highlighted and a mechanism for the role of rafts in prion conversion is proposed.
ZR 31
MH Animals; Cell Membrane/metabolism; Endocytosis; Golgi Apparatus/metabolism; Humans; Membrane Lipids/*chemistry/metabolism; Membrane Microdomains/chemistry/metabolism; Molecular Conformation; PrPc Proteins/*chemistry/metabolism; PrPsc Proteins/*chemistry/metabolism; Prion Diseases/etiology/metabolism; Prions/*chemistry/metabolism; Protein Folding; Research Support, Non-U.S. Gov't
AD Department of Biological Sciences, University of Warwick, Coventry, UK. t.pinheiro@warwick.ac.uk
SP englisch
PO Irland