NR AUZT
AU Sakudo,A.; Onodera,T.; Suganuma,Y.; Kobayashi,T.; Saeki,K.; Ikuta,K.
TI Recent advances in clarifying prion protein functions using knockout mice and derived cell lines
QU Mini Reviews in Medicinal Chemistry 2006 May; 6(5): 589-601
PT journal article; review
AB Considerable information on the functions of prion protein (PrP) has been accumulated. One experimental approach is the use of PrP gene-knockout mice and derived cell lines. This approach has contributed to elucidating the functions of cellular prion protein (PrPc), such as its anti-oxidative and anti-apoptotic roles. This review will introduce the recent advances in prion biology made possible by the availability of these tools.
ZR 202
MH Animals; Apoptosis/physiology; Cell Line; Gene Targeting; Mice; Mice, Knockout; Neurons/metabolism; Prions/chemistry/*physiology; Protein Conformation
AD Department of Virology, Center for Infectious Disease Control, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan.
SP englisch
PO Niederlande