NR AVBD
AU Liberski,P.P.; Ironside,J.W.
TI An outline of the neuropathology of transmissible spongiform encephalopathies (prion diseases)
QU Folia Neuropathologica 2004; 42 Suppl B: 39-58
PT journal article; review
AB We review here the basic neuropathology of transmissible spongiform encephalopathies (TSE) or prion diseases. The classic hallmark of TSE neuropathology is a combination (in different proportions in different diseases) of spongiform change, astrocytosis, neuronal loss and amyloid plaques. Immunohistochemically, accumulation of the abnormal isoform of prion protein (PrPsc or PrP(d)) is regarded as a diagnostic for TSE. We also review the peculiarities of kuru, variant Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease.
ZR 117
MH Animals; Brain/*pathology; Humans; Prion Diseases/*classification/*pathology; Research Support, Non-U.S. Gov't
AD Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland. ppliber@csk.am.lodz.pl
SP englisch
PO Polen