NR AVCI
AU Bautista,M.J.; Gutierrez,J.; Salguero,F.J.; Fernandez de Marco,M.M.; Romero-Trevejo,J.L.; Gomez-Villamandos,J.C.
TI BSE infection in bovine PrP transgenic mice leads to hyperphosphorylation of tau-protein
QU Veterinary Microbiology 2006 Jul 20; 115(4): 293-301
PT journal article
AB We observed the changes in the central nervous system (CNS) of transgenic mice expressing bovine prion protein (Bo-PrP) as a contribution to our knowledge of the pathogenesis of bovine spongiform encephalopathy (BSE). The main result was the detection of hyperphosphorylated tau. This protein was detected for the first time, using immunohistochemical techniques, in the neurons and glial cells of mice experimentally infected with BSE. The results highlighted the involvement of tau protein in the pathogenesis of BSE and the close link between hyperphosphorylated tau deposits and prion protein. Ultrastructural examination revealed a novel arrangement of intraneuronal tau deposits not hitherto reported.
MH Animals; Brain/*metabolism/pathology/ultrastructure; Cattle; Encephalopathy, Bovine Spongiform/etiology/*metabolism/pathology; Female; Immunohistochemistry/veterinary; Mice; Mice, Inbred CBA; Mice, Transgenic; Microscopy, Electron, Transmission/veterinary; Phosphorylation; Prions/genetics/*metabolism; Research Support, Non-U.S. Gov't; tau Proteins/*metabolism
AD Departamento de Anatomia y Anatomia Patologica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Campus de Rabanales, Carretera Madrid-Cadiz s/n, 14014 Cordoba, Spain.
SP englisch
PO Niederlande