NR AVEA
AU Marcos,Z.; Bodegas,M.E.; Sesma,M.P.; Guembe,L.
TI Characterization of PrPc-immunoreactive cells in monkey (Macaca fascicularis) gastrointestinal tract
QU Annals of the New York Academy of Sciences 2005 Apr; 1040: 387-90
PT journal article
AB The gastrointestinal tract (GIT) is one of the most likely entry sites for the pathological isoform of prions (PrPsc). To understand how PrPsc crosses the digestive mucosa, it is crucial to characterize the cells expressing normal prion protein (PrPc). By means of double immunofluorescence applied to sections of the monkey GIT, we demonstrated that, in the stomach, PrPc immunostaining occurs in subsets of histamine, somatostatin (Som), ghrelin (Ghr), gastrin (G), and serotonin (5HT) cells. In the small and large bowels, PrPc cells were found in subpopulations of cells immunolabeled for 5HT, Som, G, and peptide YY (PYY).
MH Animals; Fluorescent Antibody Technique; Gastrointestinal Tract/chemistry/*metabolism; Macaca fascicularis/*metabolism; PrPc Proteins/analysis/*chemistry/metabolism; Research Support, Non-U.S. Gov't
AD Department of Histology and Pathology, University of Navarra, School of Medicine, Pamplona, Spain. zmarcos@alumni.unav.es
SP englisch
PO USA