NR AVEW
AU Verity,C.M.; Winstone,A.M.; Stellitano,L.; Nicoll,A.; Will,R.G.
TI No clinical evidence of hidden vCJD in UK children
QU Archives of Disease in Childhood 2006 Jul; 91(7): 608-9
KI Arch Dis Child. 2006 Jul;91(7):551-3. PMID: 16790718
PT journal article
AB Between May 1997 and November 2004 this national prospective surveillance study identified 1007 children with "progressive intellectual and neurological deterioration" (PIND). In most cases specific diagnoses were made, but of 92 undiagnosed children with PIND 46 had died and only four underwent full necropsy. There was no clinical evidence of variant Creutzfeldt-Jakob disease (vCJD) in these undiagnosed cases, but without necropsy it is not possible to exclude vCJD completely.
MH Adolescent; Autopsy; Child; Child, Preschool; Creutzfeldt-Jakob Syndrome/diagnosis/*epidemiology; Female; Great Britain/epidemiology; Humans; Infant; Infant, Newborn; Magnetic Resonance Imaging; Male; Research Support, Non-U.S. Gov't
AD Addenbrooke's Hospital, Cambridge, UK. christopher.verity@addenbrookes.nhs.uk
SP englisch
PO England