NR AVGP
AU Solassol,J.; Pastore,M.; Crozet,C.A.; Perrier,V.; Lehmann,S.
TI A novel copper-hydrogen peroxide formulation for prion decontamination
QU Journal of Infectious Diseases 2006 Sep 15; 194(6): 865-9
PT journal article
AB With the appearance of variant Creutzfeldt-Jakob disease (CJD) and the detection of infectious prions in the peripheral organs of persons with sporadic CJD, the development of decontamination methods that are compatible with medical equipment has become a major issue. Here, we show that a formulation of copper metal ions in combination with hydrogen peroxide dramatically reduces the level of prion protein (PrP)(Sc) (the scrapie isoform of PrP) present in homogenates of samples from prion-infected brains, including brain samples from humans with CJD. An animal bioassay confirmed the reduction in prion infectivity, indicating that this novel Cu(2+)-H(2)O(2) formulation has great potential for prion decontamination.
MH Animals; Anti-Infective Agents, Local/pharmacology; Biological Assay; Brain/microbiology; Comparative Study; Copper/*pharmacology; Creutzfeldt-Jakob Syndrome/prevention & control; Decontamination/*methods; Humans; Hydrogen Peroxide/*pharmacology; Mice; Mice, Inbred C57BL; Prion Diseases/microbiology/*prevention & control; Prions/*drug effects; Research Support, Non-U.S. Gov't; Scrapie/prevention & control; Trace Elements/pharmacology
AD Institut de Genetique Humaine du Centre National de la Recherche Scientifique, UPR1142, 34396 Montpellier, France. j-solassol@chu-montpellier.fr
SP englisch
PO USA