NR AVLI
AU May,B.C.H.; Witkop,J.; Sherrill,J.; Anderson,M.O.; Madrid,P.B.; Zorn,J.A.; Prusiner,S.B.; Cohen,F.E.; Guy,R.K.
TI Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells
QU Bioorganic & Medicinal Chemistry Letters 2006 Sep 15; 16(18): 4913-6
PT journal article
AB A focused library of variously substituted 9-aminoacridine compounds was screened for bioactivity against accumulation of the infectious prion protein isoform, denoted PrPsc, in a cell model of prion replication. The efficacy of compounds against PrPsc accumulation was influenced by both substituents of the distal tertiary amine and acridine heterocycle, while cellular cytotoxicity was encoded in the acridine heterocycle substituents.
MH Aminacrine/*chemistry/*pharmacology; Cell Line; Cell Survival/drug effects; Humans; Molecular Structure; Neuroblastoma/*pathology; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; *Scrapie; Structure-Activity Relationship
AD Barnaby C. H. May (bmay@ind.ucsf.edu), Juanita Witkop, Stanley B. Prusiner, Institute for Neurodegenerative Diseases, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA; Barnaby C. H. May, Stanley B. Prusiner, Department of Neurology, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA; John Sherrill, Julie A. Zorn, Fred E. Cohen, Department of Cellular and Molecular Pharmacology, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA; Stanley B. Prusiner, Department of Biochemistry and Biophysics, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA; Marc O. Anderson, Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132, USA; Peter B. Madrid, SRI International, Biosciences Division, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA; R. Kiplin Guy, Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794, USA
SP englisch
PO England