NR AVNZ
AU Riemer,C.; Bamme,T.; Mok,S.W.F.; Baier,M.
TI 3-Methyl-4-chlorophenol for prion decontamination of medical devices
QU Infection Control and Hospital Epidemiology 2006 Jul; 27(7): 778-80
PT journal article
AB Disinfectants containing 3-methyl-4-chlorophenol were tested for their capacity to inactivate the infectious agent of scrapie. Coincubation of brain homogenates prepared from terminally ill scrapie-infected hamsters with the disinfectants rendered the prion protein PrPsc sensitive to proteinase K digestion. Inoculation of hamsters with disinfectant-treated samples indicated a reduction in infectivity levels to below the limit of detection.
MH Blotting, Western; *Chlorophenols; *Disinfectants; *Equipment and Supplies; *Prions
AD Robert-Koch-Institut, Nordufer, Germany.
SP englisch
PO USA