NR AVRR
AU Swanton,E.; High,S.
TI ER targeting signals: more than meets the eye?
QU Cell 2006 Dec 1; 127(5): 877-9
KZ Cell. 2006 Dec 1;127(5):999-1013. PMID: 17129784
PT comment; journal article; research support, non-u.s. gov't
AB The signal sequences that target newly synthesized proteins to the endoplasmic reticulum are highly variable; however, the functional significance of this diversity has remained obscure. In this issue, Kang et al. (2006) report that variability in signal sequences allows the cell to selectively regulate the translocation of proteins into the endoplasmic reticulum in a substrate-specific manner.
MH Animals; Endoplasmic Reticulum/*metabolism; Humans; Molecular Chaperones/metabolism; Prions/chemistry/metabolism; Protein Folding; *Protein Sorting Signals; Protein Transport
AD Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK. lisa.swanton@manchester.ac.uk
SP englisch
PO USA