NR AVSG
AU Cordery,R.J.; MacManus,D.; Godbolt,A.; Rossor,M.N.; Waldman,A.D.
TI Short TE quantitative proton magnetic resonance spectroscopy in variant Creutzfeldt-Jakob disease
QU European Radiology 2006 Aug; 16(8): 1692-8
PT comparative study; journal article; research support, non-u.s. gov't
AB Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegenerative disorder. Clinical diagnosis is difficult in the early stages as the disease often presents with non-specific psychiatric and neurological symptoms. To investigate the diagnostic potential of quantitative short TE in vivo MRS, and the nature and anatomical distribution of biochemical abnormalities in vCJD, localised single-voxel spectra (TE/TR 30 ms/2,000 ms) were acquired from three brain regions: thalami, caudate nuclei and frontal white matter. Metabolite concentrations and ratios from three patients with definite or probable vCJD were compared with eight normal age-matched controls. Abnormal signal on T2-weighted MRI was apparent in the pulvinar region in all vCJD patients; this region also showed greatly increased myo-inositol [MI] (mean 2.5-fold, P=0.01) and decreased N-acetyl-aspartate (NAA; mean 2-fold, P=0.01). Two patients also showed increased [MI] (z=17, 11; one with decreased NAA, z=-12) in normal-appearing caudate nuclei. The magnitude of metabolite abnormalities in the thalami in moderately advanced vCJD suggests a potential role in earlier diagnosis. Short TE protocols allow the measurement of MI, which adds discriminant power to the MRS examination.
MH Adult; Aspartic Acid/analogs & derivatives/metabolism; Case-Control Studies; Choline/metabolism; Creatine/metabolism; Creutzfeldt-Jakob Syndrome/*metabolism; Female; Glutamic Acid/metabolism; Humans; Inositol/metabolism; Magnetic Resonance Spectroscopy/*methods; Male; Phosphocreatine/metabolism; Protons; Statistics, Nonparametric
AD Dementia Research Group, Institute of Neurology, University College London, London, UK
SP englisch
PO Deutschland