NR AVSO
AU Galkin,A.P.; Mironova,L.N.; Zhuravleva,G.A.; Inge-Vechtomov,S.G.
TI [Yeast prions, mammalian amyloidoses, and the problem of proteomic networks]
QU Genetika 2006 Nov; 42(11): 1558-70
PT english abstract; journal article; review
AB Prion proteins are infective amyloids and cause several neurodegenerative diseases in humans and animals. In yeasts, prions are expressed as cytoplasmic heritable determinants of a protein nature. Yeast prion [PSI], which results from a conformational rearrangement and oligomerization of translation termination factor eRF3, is used as an example to consider the structural - functional relationships in a potentially prion molecule, specifics of its evolution, and interactions with other prions, which form so-called prion networks. In addition, the review considers the results of modeling mammalian prion diseases and other amyloidoses in yeast cells. A hypothesis of proteomic networks is proposed by analogy with prion networks, involving interactions of different amyloids in mammals.
ZR 94
MH Amyloid/chemistry/metabolism; Amyloidosis/*metabolism; Humans; *Models, Biological; Prion Diseases/*metabolism; Prions/chemistry/*metabolism; Protein Conformation; Proteome/metabolism; Saccharomyces cerevisiae Proteins/chemistry/*metabolism
SP russisch
PO Russia (Federation)