NR AVXT
AU Moussa,A.; Coleman,A.W.; Bencsik,A.A.; Leclere,E.; Perret,F.; Martin,A.; Perron,H.
TI Use of streptomycin for precipitation and detection of proteinase K resistant prion protein (PrPsc) in biological samples
QU Chemical Communications (Cambridge, England) 2006 Mar 7(9): 973-5
PT journal article
AB The ability of streptomycin to form multimolecular aggregates with pathogenic prion proteins and their recovery by precipitation via a low-speed centrifugation step has been demonstrated; these novel properties of streptomycin make it a useful substance that increases the sensitivity of laboratory diagnostic techniques for prion infections in man and animals.
MH Animals; Cattle; Endopeptidase K/*metabolism; Molecular Structure; PrPsc Proteins/*isolation & purification/*metabolism; Precipitation; Solubility; Streptomycin/*chemistry
AD Agence Francaise de Securite Sanitaire des Aliments, Site de Lyon F69364, France. moussa69@club-internet.fr
SP englisch
PO England