NR AWAW
AU Aguzzi,A.
TI Recent progress in prion biology
QU International Conference - Prion 2006: Strategies, advances and trends towards protection of society - 3.10.-6.10.2006, Torino, Italy, Lingotto Conference Centre - Oral sessions ORAL-41
PT Konferenz-Vortrag
AB Transmissible spongiform encephalopathies (TSE) are fatal neurodegenerative diseases of humans and animals. The underlying infectious agent, the prion, accumulates not only in the central nervous system (CNS) but also in secondary lymphoid organs. I will revisit the role of the immune system in peripheral prion pathogenesis, while focusing on the mechanisms by which extraneural and extralymphatic prion infectivity develops. Interestingly, the same pro-inflammatory cytokines and homeostatic chemokines that are involved in lymphoid neogenesis and compartmentalization of immune cells appear to represent the crucial molecular switches responsible for the establishment of extraneural prion reservoirs.
AD Institute of Neuropathology, Department of Pathology, University Hospital of Zürich, CH-8091 Zürich, Switzerland. E-mail: adriano.aguzzi@usz.ch
SP englisch
PO Italien