NR AWFG
AU Geschwind,M.D.; Raudabaugh,B.J.; Haman,A.; Devereux,G.; Kramer,J.H.; Miller,B.L.
TI Creutzfeldt-Jakob disease is a profoundly behavioral disorder
QU International Conference - Prion 2006: Strategies, advances and trends towards protection of society - 3.10.-6.10.2006, Torino, Italy, Lingotto Conference Centre - Poster sessions DIA-15
PT Konferenz-Poster
AB We evaluated the extent and pattern of neuropsychiatric involvement in Creutzfeldt-Jakob Disease. There has been a dearth of formal evaluation of the neuropsychiatric features of sporadic (sCJD) and genetic (gCJD) forms of human prion disease. As a major U.S. referral center for prion disease, we have noted behavioral symptoms to be rather prominent, early features. The neuropsychiatric features of vCJD have been formally evaluated and are profound, yet few, if any, studies have formally evaluated the behavioral features of sCJD and gCJD. The Neuropsychiatric Inventory (NPI; Cummings 1997) is a validated measure for assessing behavioral features in neurodegenerative diseases. Caregivers of 45 CJD subjects (36 sCJD & 9 gCJD), 46 frontotemporal dementia (FTD) subjects, and 199 Alzheimer's disease (AD) subjects were administered the NPI at initial presentation to our center. SPSS was used for statistical analysis; chi-squares (Pearson), one-way ANOVA (Tukey), and Pearson Correlation analysis. Due to multiple comparisons, a cut off of p < 0.001 significance was used. The most common behavioral changes in CJD were depression (65%), apathy (65%), and eating/appetite (63%). In contrast, the most common behavioral changes in FTD were apathy (90%), eating/appetite disorder (88%), and disinhibition (83%) and in AD were apathy (49%), depression (43%), and anxiety (38%). CJD subjects had worse delusions, hallucinations and depression than FTD and AD.CJD was similar to FTD in anxiety, aberrant motor behavior, sleep problems, agitation and euphoria. Behavioral features are a very common in sCJD and gCJD and may be the earliest manifestations of the illness. As a behavioral disorder, CJD lies along a spectrum between AD and FTD, often closer to FTD. Inclusion of neuropsychiatric features in diagnostic criteria needs to be evaluated and may improve diagnostic sensitivity and allow for early diagnosis.
AD Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA. E-mail: mgeschwind@memory.ucsf.edu
SP englisch
PO Italien