NR AWNE
AU Sandberg,M.K.; Desbruslais,M.; Joiner,S.; Linehan,J.; Wadsworth,J.; Cunningham,A.A.; Collinge,J.
TI Piron disease in exotic species
QU International Conference - Prion 2006: Strategies, advances and trends towards protection of society - 3.10.-6.10.2006, Torino, Italy, Lingotto Conference Centre - Poster sessions PR-29
PT Konferenz-Poster
AB Bovine spongiform encephalopathy (BSE) is known to be caused by a relatively promiscuous prion strain which appears able to infect other mammalian species readily by the oral route. In addition, BSE prions have resulted in subclinical prion infection, with no clinical dysfunction observed during the normal life span of the animal, in some animal models. During the epidemic of BSE in the United Kingdom not only cattle were affected by this disease but also gemsbok, nyala, American bison, scimitar-horned oryx, Arabian oryx, eland, greater kudu, cheetahs, puma, ocelots, African lions, tigers and domestic cats. These species had been exposed to contaminated meat and bone meal or bovine carcasses. Additionally, an African lion and a tiger from British zoos developed clinical signs suggestive of prion infection but without spongiform lesions in the brain. Transmission studies were performed to investigate if these animals were affected by a prion disease and whether it was caused by the BSE prion strain. Brain tissue homogenates from these exotic animals were inoculated intracerebrally into wildtype (FVB and RIIIS/J) and transgenic mice expressing human 129MM or 0/0 129VV genotype on a Prnp background. Similar transmission characteristics as cattle BSE were seen and both neuropathology and Western blot analysis of PrPsc glycoforms showed a BSE-like profile. In several groups, mice showed subclinical prion infection. Molecular and biological strain typing are consistent with BSE aetiology for lion and tiger prion disease.
AD M.K. Sandberg, M. Desbruslais, S. Joiner, J. Linehan, J. Wadsworth, J. Collinge: Medical Research Council Prion Unit, Institute of Neurology, University of College London, London, United Kingdom; A.A. Cunningham: Institute of Zoology, Regent's Park, London, United Kingdom
SP englisch
PO Italien