NR AWOJ
AU Steele,A.D.; Lindquist,S.L.
TI Prion protein in health and disease
QU International Conference - Prion 2006: Strategies, advances and trends towards protection of society - 3.10.-6.10.2006, Torino, Italy, Lingotto Conference Centre - Poster sessions PA-54
PT Konferenz-Poster
AB The normal function of the prion protein (PrP) remains unclear. Deciphering the normal function of PrP could be of vital importance to understanding the pathogenic dysfunction of misfolded PrP in prion diseases. Recent work from our laboratory has demonstrated a function for PrP in the selfrenewal of hematopoietic stem cells and in promoting neural precursor proliferation in vivo. We have been examining PrP knockout mice for other phenotypes as a means to determine the function of PrP. Another aspect of our work focuses on understanding how the misfolding of PrP causes disease. We have inoculated mice deficient for heat shock factor 1 (Hsf1), a key stress responsive transcription factor. These mice have alterations in prion incubation time and PrPsc accumulation.
AD Whitehead Institute for Biomedical Research, MIT, Cambridge, MA USA
SP englisch
PO Italien