NR AWPD
AU Trevitt,C.R.; Collinge,J.
TI A systematic review of prion therapeutics in experimental models of prion propagation
QU International Conference - Prion 2006: Strategies, advances and trends towards protection of society - 3.10.-6.10.2006, Torino, Italy, Lingotto Conference Centre - Poster sessions THE-19
PT Konferenz-Poster
AB Over the past forty years, a large number of putative treatments for prion diseases have been studied both in humans and in experimental models. The arrival of variant CJD in the UK in the 1990s has intensified the search for effective therapeutic agents, using an increasing number of animal, cellular and in vitro models of prion propagation. To date, however, there has been little systematic analysis of the resulting data. We present here the first comprehensive, systematic review of the data on experimental approaches to prion therapeutics from the published literature. Articles detailing the effects of treatments in models of prion propagation were identified by systematic literature searches, data tabulated according to experimental type, and a summary of results by therapeutic agent type created (1). The diversity of the experimental data precludes formal meta-analyses as routinely performed with systematic reviews of clinical trials; nevertheless the availability of all data together allows some qualitative analysis, which can inform both experimental and clinical research and which is timely at the advent of clinical trials in human prion diseases. Here we show selected examples of the tabulated data from in vivo and in vitro approaches to date. (1) Trevitt C and Collinge J. A systematic review of prion therapeutics in experimental models. 2006. Brain (in press).
AD Clare R. Trevitt (c.trevitt@prion.ucl.ac.uk), John Collinge (j.collinge@prion.ucl.ac.uk), MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
SP englisch
PO Italien