NR AWPI
AU Turner,M.L.
TI Risk linked to blood
QU International Conference - Prion 2006: Strategies, advances and trends towards protection of society - 3.10.-6.10.2006, Torino, Italy, Lingotto Conference Centre - Oral sessions ORAL-07
PT Konferenz-Vortrag
AB Although Blood Services have taken a precautionary approach over the past 10 years in relation to the possibility that variant CJD may be transmissible by blood and tissues, emerging evidence that there may be a significant cohort of individuals with sub-clinical disease, along with three cases of transmission of variant CJD prions by blood components, has increased concern that blood transfusion and tissue transplantation may provide a route to extension of the outbreak of this disease. The exact level of risk remains difficult to assess because of continuing uncertainties around the prevalence of sub-clinical disease, the concentration and distribution of infectivity and the overall transmissibility of variant CJD by these routes. Similarly, the extent to which current risk reduction measures including donor selection and universal leucodepletion are effective in reducing the risk of transmission is unclear. Newer technologies including prion reduction filters and peripheral blood prion assays may provide a significant improvement in management of this risk, but there are problems in terms of validation, countervailing risks and ethical and social considerations.
AD Scottish National Blood Transfusion Service
SP englisch
PO Italien