NR AWRS
AU Fadiel,A.; Eichenbaum,K.D.; Hamza,A.; Tan,O.; Lee,H.H.; Naftolin,F.
TI Modern pathology: protein mis-folding and mis-processing in complex disease.
QU Current Protein & Peptide Science 2007 Feb; 8(1): 29-37
PT journal article; review
AB Electrostatic and electrochemical properties of bio-molecules, such as proteins, are governed by energy parameters that are, in part dependent on its folding. Disruption of this process can lead to the development of complex, multisystem diseases whose presentation may be organ-dependent. Examples include cystic fibrosis, alpha-1 antitrypsin deficiency, and Alzheimer disease. In addition to explaining exotic pathologic syndromes, an understanding of protein folding mechanisms may facilitate the understanding of less complex diseases and allow the development of novel therapeutic approaches.
ZR 104
MH Alzheimer Disease/metabolism; Amino Acid Sequence; Animals; Creutzfeldt-Jakob Syndrome/genetics/metabolism; Cystic Fibrosis/genetics/metabolism; Electrochemistry; Electrostatics; Evolution, Molecular; Humans; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes; Prions/chemistry/genetics; *Protein Folding; *Protein Processing, Post-Translational; Proteins/*chemistry/genetics/*metabolism; Proteomics; Sequence Homology, Amino Acid; Syndrome
AD Ob/Gyn Department, New York University School of Medicine, New York, NY 10016, USA. ahmed.fadiel@med.nyu.edu
SP englisch
PO Niederlande