NR AWSA
AU Konold,T.; Davis,A.; Bone,G.; Bracegirdle,J.; Everitt,S.; Chaplin,M.J.; Saunders,G.C.; Cawthraw,S.; Simmons,M.M.
TI Clinical findings in two cases of atypical scrapie in sheep: a case report.
QU BMC Veterinary Research 2007; 3: 2
IA http://www.biomedcentral.com/1746-6148/3/2
PT case reports; journal article; research support, non-u.s. gov't
AB BACKGROUND: Atypical scrapie is a recently recognised form of transmissible spongiform encephalopathy of sheep that differs from classical scrapie in its neuropathological and biochemical features. Most cases are detected in apparently healthy sheep and information on the clinical presentation is limited. CASE PRESENTATION: This report describes the clinical findings in two sheep notified as scrapie suspects and confirmed as atypical scrapie cases by immunohistochemistry and Western immunoblotting. Although both sheep displayed signs suggestive of a cerebellar dysfunction there was considerable variation in the individual clinical signs, which were similar to classical scrapie. CONCLUSION: Any sheep presenting with neurological gait deficits should be assessed more closely for other behavioural, neurological and physical signs associated with scrapie and their presence should lead to the suspicion of scrapie.
MH Animals; Brain/pathology/physiopathology; Female; PrPsc Proteins/analysis/metabolism; Scrapie/*diagnosis/metabolism/pathology/physiopathology; Sheep; Trigeminal Nucleus, Spinal/metabolism/pathology
AD Timm Konold (t.konold@vla.defra.gsi.gov.uk), Andrew Davis, Gemma Bone, Marion M. Simmons, Neuropathology, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, UK; Timm Konold (t.konold@vla.defra.gsi.gov.uk), Royal Veterinary College, Population Biology and Disease Control Research Group, North Mymms, Hatfield, UK; John Bracegirdle, State Veterinary Service Cardiff, Llandrindod Wells, Powys, UK; Sharon Everitt, Melanie Chaplin, Ginny C. Saunders, Saira Cawthraw, TSE Molecular Biology 4, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, UK
SP englisch
PO England