NR AWTO
AU Dietz,K.; Raddatz,G.; Wallis,J.; Muller,N.; Zerr,I.; Duerr,H.P.; Lefevre,H.; Seifried,E.; Löwer,J.
TI Blood transfusion and spread of variant Creutzfeldt-Jakob disease
QU Emerging Infectious Diseases 2007 Jan; 13(1): 89-96
IA http://www.cdc.gov/ncidod/eid/13/1/89.htm
PT journal article; research support, non-u.s. gov't
AB Variant Creutzfeldt-Jakob disease (vCJD) may be transmissible by blood. To prevent secondary transmission through blood components, several countries have started to exclude as donors persons who have received a blood transfusion. We investigated the effectiveness of this measure by using a dynamic age-structured model. It is the first such model based on epidemiologic data: 1) blood donor activities, 2) a case-control study on CJD, 3) age distribution of recipients, and 4) death of recipients of blood transfusions. The model predicts that an infection like vCJD, which has been introduced into the population by the alimentary route, could not become endemic by transfusion alone and that only <1% of cases would be avoided by excluding from blood donation those persons who have received a transfusion.
MH Adolescent; Adult; Aged; *Blood Donors; Blood Transfusion/*adverse effects; Creutzfeldt-Jakob Syndrome/*transmission; Humans; Incidence; Middle Aged; Models, Biological; Prevalence; Risk Factors
AD Klaus Dietz (klaus.dietz@uni-tuebingen.de), Günter Raddatz, Hans-Peter Duerr, University of Tübingen, Tübingen, Germany; Jonathan Wallis, Freeman Hospital, Newcastle upon Tyne, United Kingdom; Norbert Müller, University Hospital Essen, Essen, Germany; Inga Zerr, University of Göttingen, Göttingen, Germany; Hans Lefèvre, DRK Blood Donor Service West, Hagen, Germany; Erhard Seifried, DRK Blood Donor Service Baden-Württemberg, Hessen, Frankfurt am Main, Germany; Johannes Löwer, Paul-Ehrlich-Institute, Langen, Germany
SP englisch
PO USA