NR AWYX
AU Drabik,A.; Bierczynska-Krzysik,A.; Bodzon-Kulakowska,A.; Suder,P.; Kotlinska,J.; Silberring,J.
TI Proteomics in neurosciences
QU Mass Spectrometry Reviews 2007 May-Jun; 26(3): 432-50
PT journal article; research support, non-u.s. gov't; review
AB This review provides an outline of the most important proteomic applications in the study of neurodegenerative disorders including Alzheimer's (AD), Parkinson's (PD), Huntington's (HD), and prion diseases, and also discusses advances in cancer and addiction. One of the scopes is to illustrate the potential of proteomics in the biomarkers discovery of these diseases. Finally, this article comments the advantages and drawbacks of the most commonly used techniques and methods for samples preparation.
ZR 113
MH Biological Markers/analysis; Diagnosis, Computer-Assisted/methods; Gene Expression Profiling/*methods; Humans; Mass Spectrometry/*methods; Neurodegenerative Diseases/*diagnosis/*metabolism; Neurosciences/*methods; Peptide Mapping/methods; Proteome/*analysis; Proteomics/*methods; Specimen Handling/methods
AD Faculty of Chemistry and Regional Laboratory, Jagiellonian University, Krakow, Poland.
SP englisch
PO USA