NR AWYZ
AU Seitz,R.; von Auer,F.; Blümel,J.; Burger,R.; Buschmann,A.; Dietz,K.; Heiden,M.; Hitzler,W.E.; Klamm,H.; Kreil,T.; Kretzschmar,H.A.; Nübling,M.; Offergeld,R.; Pauli,G.; Schottstedt,V.; Volkers,P.; Zerr,I.
TI Impact of vCJD on blood supply
QU Biologicals 2007 Apr; 35(2): 79-97
PT journal article; review
AB Variant Creutzfeldt-Jakob disease (vCJD) is an at present inevitably lethal neurodegenerative disease which can only be diagnosed definitely post mortem. The majority of the approximately 200 victims to date have resided in the UK where most contaminated beef materials entered the food chain. Three cases in the UK demonstrated that vCJD can be transmitted by blood transfusion. Since BSE and vCJD have spread to several countries outside the UK, it appears advisable that specific risk assessments be carried out in different countries and geographic areas. This review explains the approach adopted by Germany in assessing the risk and considering precautionary measures. A fundamental premise is that the feeding chain of cattle and the food chain have been successfully and permanently cleared from contaminated material. This raises the question of whether transmissions via blood transfusions could have the potential to perpetuate vCJD in mankind. A model calculation based on actual population data showed, however, that this would not be the case. Moreover, an exclusion of transfusion recipients from blood donation would add very little to the safety of blood transfusions, but would have a considerable impact on blood supply. Therefore, an exclusion of transfusion recipients was not recommended in Germany.
IN Seitz et al. meinen, dass durch Blutspenden BSE-infizierter Menschen zwar Empfänger von Blutspenden infiziert werden können, dass aber nicht dadurch eine nvCJK-Epidemie erhalten werden könnte. Von einem Verzicht auf Blutspenden von Empfängern von Blutspenden würden die Autoren einen bedenklichen Einfluss auf die Blutversorgung, aber nur eine sehr geringe Reduktion des nvCJK-Risikos erwarten.
ZR 106
MH Animals; Blood Component Transfusion; Blood Donors/*supply & distribution; Blood Transfusion/adverse effects; Blood-Borne Pathogens/isolation & purification; Cattle; Creutzfeldt-Jakob Syndrome/*blood/*transmission; Encephalopathy, Bovine Spongiform/epidemiology/transmission; Germany; Humans; Incidence; Leukapheresis; Patient Selection; Ruminants
AD Rainer Seitz (seira@pei.de), Johannes Blümel, Margarethe Heiden, Micha Nübling, Peter Volkers, Paul-Ehrlich-Institut, Paul-Ehrlich-Strasse 51-59, D-63225 Langen, Germany; Friedger von Auer, Horst Klamm, Federal Ministry of Health, Bonn, Germany; Reinhard Burger, Ruth Offergeld, Georg Pauli, Robert Koch-Institut, Berlin, Germany; Anne Buschmann, Friedrich-Loeffler-Institut, Insel Riems, Germany; Klaus Dietz, Department of Medical Biometry, Eberhard-Karls-University, Tübingen, Germany; Walter E. Hitzler, Transfusion Centre, Johannes Gutenberg-University Hospital, Mainz, Germany; Thomas Kreil, Baxter AG, Vienna, Austria; Hans Kretzschmar, Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany; Volkmar Schottstedt, German Red Cross Blood Donation Service West, Hagen, Germany; Inga Zerr, Department of Neurology, Prion Research Group, University Hospital, Göttingen, Germany
SP englisch
PO England