NR AXAV
AU McHugh,J.C.; Bradley,D.; Hutchinson,M.; Brett,F.; Heffernan,J.; Howley,R.; Farrell,M.; Tubridy,N.
TI Variant Creutzfeldt-Jakob disease: first two indigenous cases in Republic of Ireland. Case report and perspective.
QU European Journal of Neurology 2007 Apr; 14(4): 467-9
PT case reports; journal article
AB The first two cases of indigenous variant Creutzfeldt-Jakob disease (vCJD) in the Republic of Ireland are reported in two men, neither of whom had lived outside Ireland. Both diagnoses were made ante-mortem based on clinical presentation, brain imaging, positive 14-3-3 protein in one case, and tonsillar biopsy. We discuss some of the clinical aspects of vCJD and the significance of these cases in the Irish context.
MH 14-3-3 Proteins/cerebrospinal fluid; Adult; Brain/*pathology; Creutzfeldt-Jakob Syndrome/*pathology; Genotype; Humans; Ireland; Magnetic Resonance Imaging; Male; Prions/genetics
AD Department of Neurology, St Vincent's University Hospital, Elm Park, Dublin, Ireland.
SP englisch
PO England