NR AXBV

AU Stanczak,P.; Valensin,D.; Juszczyk,P.; Grzonka,Z.; Valensin,G.; Bernardi,F.; Molteni,E.; Gaggelli,E.; Kozlowski,H.

TI Fine tuning the structure of the Cu2+ complex with the prion protein chicken repeat by proline isomerization

QU Chemical Communications (Cambridge, England) 2005 Jul 14(26): 3298-300

PT journal article; research support, non-u.s. gov't

AB The interaction between the single hexarepeat unit of chicken prion protein [ChPrP(54-59)] and Cu(II) was investigated by NMR, finding different coordination modes for the trans/trans and cis/trans isomers.

MH Animals; Binding Sites; Chickens; Copper/*chemistry; Magnetic Resonance Spectroscopy/methods; Models, Molecular; Organometallic Compounds/*chemistry; Prions/*chemistry; Proline/*chemistry; Protein Conformation; Protein Structure, Tertiary; Sensitivity and Specificity; Stereoisomerism; Structure-Activity Relationship

AD Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.

SP englisch

PO England

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