NR AXEB
AU Beringue,V.; Andreoletti,O.; Le Dur,A.; Essalmani,R.; Vilotte,J.L.; Lacroux,C.; Reine,F.; Herzog,L.; Biacabe,A.G.; Baron,T.G.M.; Caramelli,M.; Casalone,C.; Laude,H.
TI A bovine prion acquires an epidemic bovine spongiform encephalopathy strain-like phenotype on interspecies transmission
QU Journal of Neuroscience 2007 Jun 27; 27(26): 6965-71
PT journal article; research support, non-u.s. gov't
AB Implementation in Europe of large-scale testing to detect bovine spongiform encephalopathy (BSE)-infected cattle and prevent the transmission of this prion disease to humans has recently led to the discovery of novel types of bovine prions. We characterized atypical isolates called BSE L-type by analyzing their molecular and neuropathological properties during transmission to several mouse lines transgenic for the prion protein (PrP). Unexpectedly, such isolates acquired strain features closely similar to those of BSE-type agents when propagated in mice expressing ovine PrP, although they retained phenotypic traits distinct from BSE in other lines, including bovine PrP mice. These findings further underline the relationship between the crossing of species barrier and prion strain diversification, and, although the origin of the epidemic BSE agent has only been speculative until now, they provide new insight into the nature of the events that could have led to the appearance of this agent.
MH Animals; Brain/*metabolism/pathology/physiopathology; Cattle; Encephalopathy, Bovine Spongiform/genetics/*physiopathology/*transmission; Evolution, Molecular; Humans; Mice; Mice, Transgenic; Phenotype; Prions/*genetics/*metabolism; Species Specificity
AD Institut National de la Recherche Agronomique, Unite de Recherche 892, Virologie Immunologie Moleculaires, F-78350 Jouy-en-Josas, France. vincent.beringue@jouy.inra.fr
SP englisch
PO USA