NR AXFE
AU Doh-ura,K.; Kuge,T.; Uomoto,M.; Nishizawa,K.; Kawasaki,Y.; Iha,M.
TI Prophylactic effect of dietary seaweed Fucoidan against enteral prion infection
QU Antimicrobial Agents and Chemotherapy 2007 Jun; 51(6): 2274-7
PT journal article; research support, non-u.s. gov't
AB Dietary seaweed fucoidan delays the onset of disease of enterally infected mice with scrapie when given orally for 6 days after infection, but not when given before the infection. This effect was not modified at a tested fucoidan dose range and appeared to reach the maximum level at a concentration of 2.5% or less in feed. Daily uptake of fucoidan might be prophylactic against prion diseases caused by ingestion of prion-contaminated materials, although further evaluation of its pharmacology remains to be done.
MH *Administration, Oral; Animals; Cattle; Cell Line, Tumor; Diet; Fucose; Humans; Phytotherapy; Polysaccharides/administration & dosage/chemistry/*therapeutic use; PrPsc Proteins/*administration & dosage/pathogenicity; Prion Diseases/*prevention & control; Prions; Scrapie/prevention & control; Seaweed/*chemistry
AD Department of Prion Research, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575, Japan. doh-ura@mail.tains.tohoku.ac.jp
SP englisch
PO USA