NR AXKK
AU Chianini,F.; Gonzalez,L.; Reid,H.W.; Finlayson,J.; Hamilton,S.; Eaton,S.L.; Steele,P.J.; Martin,S.; Siso,S.; Dagleish,M.P.; Jeffrey,M.
TI Transmission Dynamics in a Suffolk Sheep Flock Naturally Infected with Scrapie as Shown by Sequential Biopsies and Necropsies
QU International Conference - Prion 2007 (26.-28.9.2007) Edinburgh International Conference Centre, Edinburgh, Scotland, UK - Book of Abstracts: Epidemiology, Risk Assessment and Transmission P04.85
IA http://www.prion2007.com/pdf/Prion Book of Abstracts.pdf
PT Konferenz-Poster
AB Tonsil biopsies and or necropsies were performed on 6 birth cohorts of a scrapie infected Suffolk sheep flock between 1998-2004 . The onset of accumulation of abnormal Prion protein in lymphoid tissue, the attack rate and age to clinical scrapie or necropsy were determined for different groups of sheep. Differences in attack rates and/or mean age to necropsy were found for different birth cohorts, for lambs born to scrapie infected sheep when compared to scrapie resistant sheep; for male and female sheep; and for prima gravida progeny compared to lambs born from later pregnancies. When husbandry conditions are taken into account, the data suggest that under natural conditions the highest risk of acquiring infection occurs in the perinatal period, probably by placental contamination of the environment. However, the data also support the probable horizontal scrapie infection occurring at low frequency in older sheep. Naturally infected flocks will experience transmissions to susceptible genotypes by high and low risk events. In this flock accumulation of abnormal PrP in lymphoid tissues occurred at approximately 50% of the age to death. When compared with previous data, this does not suggest that LRS infection is necessary for neuroinvasion.
AD F. Chianini, Hugh W. Reid, J. Finlayson, S. Hamilton, S.L. Eaton, P.J. Steele, M.P. Dagleish, Moredun Research Institute, UK; L. González, S. Martin, S. Sisó, M. Jeffrey, Veterinary Laboratory Agency, Lasswade, UK
SP englisch
PO Schottland