NR AXLZ
AU Farquhar,C.F.; Brown,K.L.; McConnell,I.; Boyle,A.; Mabbott,N.A.; Bruce,M.E.
TI The Immune System Facilitates BSE Transmission into Mice
QU International Conference - Prion 2007 (26.-28.9.2007) Edinburgh International Conference Centre, Edinburgh, Scotland, UK - Book of Abstracts: Oral Abstracts FC3.7
IA http://www.prion2007.com/pdf/Prion Book of Abstracts.pdf
PT Konferenz-Vortrag
AB TSEs (prion diseases) can present as sporadic, familial or acquired. The major host determinant of incubation period is the PrP gene, with PrP expression critical for disease. vCJD arose from food-borne BSE, and BSE transmits unusually efficiently to laboratory mice, making this a manipulable model for defining host elements involved in the transmission of TSE agents between species. We have previously demonstrated that cross species transmission does not depend on the degree of homology between donor and recipient PrP. We have also shown that there are large and consistent incubation period differences in mouse strains carrying the same Prnpa genotype and that the incubation period of the shortest strain can be prolonged by splenectomy prior to infection. In addition, we have reported that SCID mice are not susceptible to BSE infection even after intracerebral inoculation. We now report on further attempts to define the role of the immune system in the transmission of cattle BSE to mice including attempts to reconstitute susceptibility in immunodeficient mice by engraftment with immunocompetent bone marrow. We conclude that the transmission of bovine BSE requires the presence of functional follicular dendritic cells in the recipient mice. Funding BBSRC and DEFRA
AD C.F. Farquhar, K.L. Brown, I. McConnell, A. Boyle, N.A. Mabbott, M.E. Bruce, Neuropathogenesis Unit, RI, UK
SP englisch
PO Schottland