NR AXOC
AU Haybaeck,J.; Heikenwalder,M.; Margalith,I.; Zeller,N.; Bridel,C.; Schwarz,P.; Merz,K.; Stitz,L.; Aguzzi,A.
TI Intranasal and Aerosolic Prion Transmission
QU International Conference - Prion 2007 (26.-28.9.2007) Edinburgh International Conference Centre, Edinburgh, Scotland, UK - Book of Abstracts: Pathology and Pathogenesis P03.103
IA http://www.prion2007.com/pdf/Prion Book of Abstracts.pdf
PT Konferenz-Poster
AB Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases of humans and animals. Prions can colonize hosts by a variety of extracerebral routes, including parenteral injection, transdermal administration after skin scarification, and oral administration. The underlying infectious agent, the prion, was shown to accumulate not only in the central nervous system (CNS) but also in secondary lymphoid organs of affected hosts. Up to date prions were not considered to be transmissible by aerial routes. Here we have investigated the transmissibility potential of prions administered intranasally or by aerosols. Various transgenic mouse models expressing the cellular prion protein (PrPc) in specific compartments or cells of the brain (e.g. exclusively in the CNS) were investigated to identify the cellular and molecular mechanism(s) of prion invasion via the intranasal or aerosolic route. Results of this study identify prion aerosols or prions administered intranasally as a startlingly efficacious pathway of prion transmission, and call for appropriate revisions of prionrelated biosafety guidelines. We currently investigate the mechanism of this transmission route.
AD J. Haybaeck, M. Heikenwalder, I. Margalith, N. Zeller, C. Bridel, P. Schwarz, K. Merz, A. Aguzzi, University Hospital Zürich, Institute of Neuropathology, Switzerland; L. Stitz, Friedrich-Löffler Institute, Immunology, Germany
SP englisch
PO Schottland
EA pdf-Datei und Poster (Posterautoren ergänzt um D. Marino und E. Gagulic)