NR AXQA
AU Knight,R.; Stewart,L.; Rydzewska,L.; Keogh,G.; Chalmers,I.; Firkins,L.; Walker,S.
TI A Systematic Review of Therapeutic Interventions for Human Prion Disease
QU International Conference - Prion 2007 (26.-28.9.2007) Edinburgh International Conference Centre, Edinburgh, Scotland, UK - Book of Abstracts: Oral Abstracts FC5.4
IA http://www.prion2007.com/pdf/Prion Book of Abstracts.pdf
PT Konferenz-Vortrag
AB The concerns generated by the identification of variant CJD have led to increased research into the nature and treatment of human prion diseases. In order to inform current and future clinical treatment trials, the UK MRC instigated a systematic review of research into the natural history and treatment of human prion diseases. Using a defined protocol, a systematic search of reports relating to human clinical studies was undertaken for the years 1966 to 2005. The study has just been updated to 2007 for reports concerning treatment of patients. The methodology involved publications and conference proceedings. Foreign language papers were included, with translations being obtained. Analysis involved identifying overlapping data from the same patients in different publications and reviews.The data were collated and summarised for the outcome in untreated and treated cases. The final analysis contained 139 publications, involving >9000 patients in 32 countries. A wide range of disease duration was reported. There were 28 reports related to 14 different drug treatments, but many such reports involved only 3 or fewer patients. More data were available for 4 drugs: Amantadine, Pentosan Polysulphate, Quinacrine and Flupirtine, allowing more detailed analysis for these treatments.There was, however, only one study using a randomisation (with Flupirtine). The detailed results will be presented. The data should provide an informed basis for the design and conduct of future treatment trials. Such studies of disease course and treatment should take place in a structured framework, with significant numbers of patients, preferably with a randomised controlled design. Richard Knight, Lesley Stewart, Larysa Rydzewska, Geraldine Keogh, Iain Chalmers, Lester Firkins, Sarah Walker.
AD R. Knight, NCJDSU, NCJDSU, UK; L. Stewart, MRC CTU, UK; L. Rydzewska, S. Walker, MRC, Clinical Trials Unit, UK; G. Keogh, National Prion Clinic, UK; I. Chalmers, James Lind Library, UK; L. Firkins, MRC, UK
SP englisch
PO Schottland