NR AXRV
AU Macfarlane,R.G.; Scahill,R.; Yousry,T.A.; Collinge,J.; Wroe,S.J.
TI A Correlation of Magnetisation Transfer Ratio Histogram Measures with Clinical Disease Severity in Inherited Prion Disease
QU International Conference - Prion 2007 (26.-28.9.2007) Edinburgh International Conference Centre, Edinburgh, Scotland, UK - Book of Abstracts: Epidemiology, Risk Assessment and Transmission P04.67
IA http://www.prion2007.com/pdf/Prion Book of Abstracts.pdf
PT Konferenz-Poster
AB Inherited prion diseases (IPD) are progressive neurodegenerative disorders in which conventional magnetic resonance (MR) neuroimaging is often unremarkable. We investigated global and regional cerebral MR magnetisation transfer ratios (MTRs) in IPD. Twenty-three patients, recruited into the MRC PRION-1 Trial, underwent MTR and conventional MR imaging. For each patient, whole-brain MTR histogram mean (AVMTR), peak height (PH), peak location (PL), and MTR at the 25th, 50th and 75th percentile (MTR25%, MTR50%, MTR75%) were calculated together with mean MTR for bilateral caudate, putaminal and pulvinar regions of interest (ROI). A clinician's assessment of disease severity (GIC), clinician's dementia rating (CDR), Alzheimer's disease assessment scale (ADAS-COG), activities of daily living (ADL), brief psychiatric rating scale (BPRS), mini mental score examination (MMSE) and Rankin scores were evaluated. Significant (p<0.01) bivariate Spearman rank correlations were found between AVMTR and Rankin (p=0.008), CDR (p=0.002) and ADAS-COG (p=0.004); PH and Rankin (p=0.002); MTR25% and Rankin (p=0.001), CDR (p<0.001), ADAS-COG (p=0.008) and GIC (p=0.006); and MTR50% and Rankin (p=0.004). Mean ROI MTRs did not correlate with clinical scores, and there were no pathological appearances on conventional MR imaging. Whole-brain MTR histogram measures may provide valuable indices of IPD disease severity for future therapeutic trials.
AD R.G. Macfarlane, J. Collinge, S.J. Wroe, Dept of Neurodegenerative disease, Institute of Neurology, MRC Prion Unit, UK; R. Scahill, Institute of Neurology, Dementia Research Group, UK; T.A. Yousry, National Hospital of Neurology and Neurosurgery, Lysholm Department of Neuroradiology, UK
SP englisch
PO Schottland
EA pdf-Datei und Poster (Posterautoren: S.J. Woe, D. Siddique, H. Hyare, T. Webb, S. Pal, J. Collinge, S. Walker, T. Yousry und J. Thornton)