NR AXRW
AU Maddox,R.; Belay,E.D.; Curns,A.T.; Nowicki,S.; Lembach,R.G.; Geschwind,M.D.; Haman,A.; Shinozaki,N.; Nakamura,Y.; Borer,M.J.; Schonberger,L.B.
TI Creutzfeldt-Jakob Disease in Recipients of Corneal Transplants
QU International Conference - Prion 2007 (26.-28.9.2007) Edinburgh International Conference Centre, Edinburgh, Scotland, UK - Book of Abstracts: Epidemiology, Risk Assessment and Transmission P04.117
IA http://www.prion2007.com/pdf/Prion Book of Abstracts.pdf
PT Konferenz-Poster
AB
Background: Five cases of corneal graft-associated Creutzfeldt-Jakob disease (CJD) have been described since 1974, when the first case was reported. Because of the large number of corneal transplant procedures, some sporadic CJD patients are likely to have a history of corneal transplantation. Determining a causal link between transplant and CJD illness may be difficult due to lack of neuropathologic testing to
confirm the disease and the absense of available donor data because of a long incubation period.
Methods: CJD cases with a history of corneal transplantation were reported to the Centers for Disease Control and Prevention, and medical records for these cases were reviewed to assess each patient's illness and the presence of any additional CJD risk factors. If possible, records from the eye bank that processed the corneas were examined to gather information on the cornea donors and on the recipients of the donors' other corneas. The National Prion Disease Pathology Surveillance Center performed genetic and neuropathologic testing on available specimens. Statistical analyses were performed to determine the occurrence of coincidental CJD among corneal transplant recipients.
Results: Four CJD decedents with histories of corneal transplantation were identified, three from the United States and one from Japan. The time from transplant to onset of CJD symptoms ranged from about 3 years to 18 years. Available eye bank records did not suggest evidence of neurologic illness in the donors. Based on corneal transplantation and CJD death data from 1990-2006, statistical analyses suggest that, on average, a case of coincidental sporadic CJD in a corneal transplant recipient is expected to occur approximately every 1.5 years.
Conclusions: It is likely that these four recipients of transplanted corneas had sporadic CJD. Because of the high number of corneal transplantations performed each year in the United States, occasional cases of sporadic CJD in this population are expected.
AD R. Maddox, E.D. Belay, A.T. Curns, L.B. Schonberger, Centers for Disease Control and Prevention, USA; S. Nowicki, Ohio Department of Health, USA; R.G. Lembach, Central Ohio Lions Eye Bank, USA; M.D. Geschwind, A. Haman, University of California, San Francisco, Memory and Aging Center, Department of Neurology, USA; N. Shinozaki, Ichikawa General Hospital, Tokyo Dental College, Cornea Center, Japan; Y. Nakamura, Jichi Medical University, Department of Public Health, Japan; M.J. Borer, Tissue Banks International, USA
SP englisch
PO Schottland