NR AXYL
AU Ward,H.J.T.; Sneddon,J.; Reilly,J.; Chow,Y.; Soldan,K.; Knight,R.S.G.; Will,R.G.
TI Variant CJD: A Review of Individuals Designated "at Risk" due to Exposure through Medical Procedures or Blood Transfusion
QU International Conference - Prion 2007 (26.-28.9.2007) Edinburgh International Conference Centre, Edinburgh, Scotland, UK - Book of Abstracts: Epidemiology, Risk Assessment and Transmission P04.13
IA http://www.prion2007.com/pdf/Prion Book of Abstracts.pdf
PT Konferenz-Poster
AB
Introduction: Variant CJD (vCJD) is caused by human infection with the bovine spongiform encephalopathy (BSE) agent. Concerns about the possibility of a large UK epidemic of vCJD due to the past extensive exposure of the human population to BSE have receded, with recent mathematical models predicting that the primary outbreak of clinical cases may be relatively restricted. However, reports of four incidents of transmission of vCJD infection via blood transfusion raise the possibility of a selfsustaining secondary epidemic.
Methods: The CJD Incidents Panel (CJDIP) was established by the UK Chief Medical Officers in 2000 with the remit of managing incidents involving potential transmission of CJD between patients through invasive medical procedures, including blood transfusion, surgery and organ and tissue transplants. Potential healthcare exposures are reported to the CJDIP and, depending on the estimated level of risk, public health measures are implemented, including quarantining of instruments and notification of possible 'contacts' of their status as "at risk of CJD for public health purposes".
Results: To date, there are five groups of individuals who have been designated "at risk of CJD" through potential exposure to vCJD: 1) those exposed to potentially contaminated healthcare instruments; 2) recipients of blood from donors who later developed vCJD; 3) recipients of certain plasma-products; 4) donors of blood to people who developed vCJD, and 5) recipients of blood from certain 'at-risk' donors. This paper describes the process of notification and risk assessment, the "at-risk" categories, including the numbers designated "at-risk" and their follow up, and considers the policy implications.
Conclusion: The follow up of these groups is essential to determine whether transmission of vCJD has occurred through routes other than through blood transfusion. This will inform public health policy in the UK and elsewhere.
AD H.J.T. Ward, R.S.G. Knight, R.G. Will, National CJD Surveillance Unit, UK; J. Sneddon, J. Reilly, Health Protection Scotland, UK; Y. Chow, K. Soldan, Health Protection Agency, UK
SP englisch
PO Schottland
EA pdf-Datei und Poster (Posterautoren ergänzt um D. Brookes)